Recognition and regulation of primary-sequence motifs by signaling modular domains
نویسندگان
چکیده
منابع مشابه
Autoinhibitory domains: modular effectors of cellular regulation.
Autoinhibitory domains are regions of proteins that negatively regulate the function of other domains via intramolecular interactions. Autoinhibition is a potent regulatory mechanism that provides tight "on-site" repression. The discovery of autoinhibition generates valuable clues to how a protein is regulated within a biological context. Mechanisms that counteract the autoinhibition, including...
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Infection with enterotoxigenic Escherichia coli is a leading cause of traveler's diarrhea. Many enterotoxigenic E. coli strains produce heat-stable enterotoxin (ST), a peptide that binds to the intestinal receptor guanylyl cyclase C known as STaR. The toxin-receptor interaction elevates intracellular cGMP, which then activates apical chloride secretion, resulting in secretory diarrhea. In this ...
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Living cells display complex signal processing behaviors, many of which are mediated by networks of proteins specialized for signal transduction. Here we focus on the question of how the remarkably diverse array of eukaryotic signaling circuits may have evolved. Many of the mechanisms that connect signaling proteins into networks are highly modular: The core catalytic activity of a signaling pr...
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Macrophages express a cell surface receptor which mediates phagocytosis and pinocytosis of particles and solutes containing mannose (fucose and N-acetylglucosamine are also ligands for the receptor). An apparently identical protein has been isolated from human placenta. Proteolytic fragments of the placental receptor were sequenced so that oligonucleotide probes complementary to the receptor cD...
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Remote protein homology detection is an important step towards understanding protein function in living organisms. The problem is notoriously difficult; distant homologs can often be detected only by a combination of sequence and structural features. We propose a new framework, where important sequence and structural features are described by the user in the form of a descriptor, and the descri...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 1999
ISSN: 0079-6107
DOI: 10.1016/s0079-6107(98)00045-5